​Robart  lab

RNA Biochemistry / Structural Biology

publications

Geldenhuys WJ, Long TE, Saralkar P, Iwasaki T, Nuñez RAA, Nair RR, Konkle ME, Menze MM, Pinti MV, Hollander JM, Hazlehurst LA, Robart AR. (2019)
Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand. Communications Chemistry. 


Smathers CM & Robart AR. (2019) The mechanism of splicing as told by group II introns: ancestors of the spliceosome. BBA Gene Regulatory Mechanisms.


Geldenhuys WJ, Skolik R, Konkle ME, Menze MA, Long TE, Robart AR. (2019) Binding of thiazolidinediones to the endoplasmic reticulum protein nutrient-deprivation autophagy factor-1.  Bioorganic & Medicinal Chemistry. 29(7) 


Hayes KE, Batsomboon P, Chen WC, Johnson BD, Becker A, Eschrich S, Yang Y, Robart AR, Dudley GB, Geldenhuys WJ, Hazlehurst LA. (2019) Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma. Bioorganic & Medicinal Chemistry. 27(8) 


Chan RT, Peters JK, Robart AR, Wiryaman T, Rajashankar KR, Toor N. (2018) Structural basis for the second step of group II intron splicing. Nature Communications. 9(1).


Robart AR, Chan RT, Peters JK,  Rajashankar KR, Toor N. (2014) Crystal structure of a eukaryotic group II intron lariat. Nature. 514(7521):193-7.

Chan RT, Robart AR, Kanagalaghatta R, Pyle AM, Toor N. (2012) Crystal Structure of a Group II Intron in the Pre-Catalytic State. Nature Structural and Molecular Biology. 19(5):555-7.
 

Robart AR and Collins K (2011) Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation. Molecular Cell. 42:308-18.

Robart AR and Collins K (2010) Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem. 285:4375-86.

Robart AR, O’Connor CM, Collins K (2010) Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability.  RNA. 16:563-71.

Robart AR, Seo W, Zimmerly S (2007) Insertion of group II intron retroelements after intrinsic transcriptional terminators. PNAS 104(16):6620-5

Toor N, Robart AR, Christianson J, Zimmerly S (2006) Self-splicing of a group IIC intron: 5’ exon recognition and alternative 5’ splicing events implicate the stem-loop motif of a transcriptional terminator. Nucleic Acids Res. 34(22):6461-71

Robart AR and Zimmerly S. (2005) Group II intron retroelements: function and diversity. Cytogenet Genome Res. 110 (1-4):589-97.

Robart AR, Montgomery NK, Smith KL, Zimmerly S. (2004). Principles of 3' splice site selection and alternative splicing for an unusual group II intron from Bacillus anthracis. RNA. 10:854-862.